Superoxide Radical Dismutation as New Therapeutic Strategy in Parkinson’s Disease
نویسندگان
چکیده
منابع مشابه
Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide.
Dismutation of superoxide has been shown previously to be catalyzed by stable nitroxide compounds. In the present study, the mechanism of superoxide (.O2-) dismutation by various five-membered ring and six-membered ring nitroxides was studied by electron paramagnetic resonance spectrometry, UV-visible spectrophotometry, cyclic voltammetry, and bulk electrolysis. Electron paramagnetic resonance ...
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O2- oxidizes the [4Fe-4S] clusters of dehydratases, such as aconitase, causing-inactivation and release of Fe(II), which may then reduce H2O2 to OH- +OH.. SODs inhibit such HO. production by scavengingO2-, but Cu, ZnSODs, by virtue of a nonspecific peroxidase activity, may peroxidize spin trapping agents and thus give the appearance of catalyzing OH. production from H2O2. There is a glycosylate...
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ژورنال
عنوان ژورنال: Aging and Disease
سال: 2018
ISSN: 2152-5250
DOI: 10.14336/ad.2017.1018